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Know the multiple factors that can impact theIncidence of vod

Incidence of VOD based on a meta-analysis1

Incidence of VOD Incidence of VOD

Historically, factors that may impact incidence include1-4

  • Underlying disease
  • Diagnostic criteria
  • Type of transplant
  • Conditioning regimen

Incidence of VOD based on the type of transplant and conditioning regimen

Type of transplant

Incidence based on transplant Incidence based on transplant

Conditioning regimen

Incidence based on conditioning regimen Incidence based on conditioning regimen
Reduced-intensity conditioning does not eliminate the risk of VOD, as many other factors can put patients at risk3,7,8
  1. Moderate-to-severe VOD.

HSCT=hematopoietic stem-cell transplantation; MAC=myeloablative conditioning; RIC=reduced-intensity conditioning; VOD=veno-occlusive disease (also known as sinusoidal obstruction syndrome, or SOS).

References: 1. Coppell JA, Richardson PG, Soiffer R, et al. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant. 2010;16(2):157-168. 2. Carreras E, Díaz-Beyá M, Rosiñol L, et al. The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade. Biol Blood Marrow Transplant. 2011;17(11):1713-1720. 3. Tsirigotis PD, Resnick IB, Avni B, et al. Incidence and risk factors for moderate-to-severe veno-occlusive disease of the liver after allogeneic stem cell transplantation using a reduced intensity conditioning regimen. Bone Marrow Transplant. 2014;49(11):1389-1392. 4. Cheuk DK, Wang P, Lee TL, et al. Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation. Bone Marrow Transplant. 2007;40(10):935-944. 5. Nagler A, Labopin M, Berger R, et al. Allogeneic hematopoietic SCT for adults AML using i.v. BU in the conditioning regimen: outcomes and risk factors for the occurrence of hepatic sinusoidal obstructive syndrome. Bone Marrow Transplant. 2014;49(5):628-633. 6. Corbacioglu S, Cesaro E, Faraci M, et al. Lancet. 2012;379(9823):1301-1309. 7. Mohty M, Malard F, Abecassis M, et al. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation. Bone Marrow Transplant. 2016;51(7):906-912. 8. Mohty M, Malard F, Abecassis M, et al. Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant. 2015;50(6):781-789.